Systemic arterial blood pressure determines the therapeutic window of non-selective beta blockers in decompensated cirrhosis
نویسندگان
چکیده
منابع مشابه
Nonselective Beta-blockers in Patients with Cirrhosis: "the Therapeutic Window".
For over 30 years, nonselective beta-blockers (NSBB) have been successfully used for preventing variceal bleeding in patients with cirrhosis and portal hypertension. Nevertheless, recent studies suggest that NSBB may be effective only within a particular "therapeutic window" in patients with advanced liver disease. Outside of this window, in early stages of cirrhosis and in very advanced cirrho...
متن کاملBeta-blockers in liver cirrhosis
Since the original description of the effectiveness of β-blockers in lowering the portal pressure and therefore the risk of variceal bleeding, more than 500 articles in the English literature on the use of non selective β-blockers (NSBB) in cirrhosis have been published. The use of NSBB in pre-primary prophylaxis of variceal bleeding is currently not indicated. In primary prophylaxis, patients ...
متن کاملSelective and non-selective beta receptor blockade in the reduction of portal pressure in patients with cirrhosis and portal hypertension.
To elucidate the mechanisms by which beta receptor blockade leads to a reduction of portal pressure, 18 patients with cirrhosis and portal hypertension were given comparable doses of propranolol or metoprolol. The fall in portal pressure was more marked with propranolol together with a significant reduction in hepatic blood flow, which was not seen with metoprolol. No correlation between the re...
متن کاملPressures in the pial arterial microcirculation of the cat during changes in systemic arterial blood pressure.
Dynamic arterial blood pressures were recorded by micropuncture of 99 cortical surface arteries and arterioles in cats anesthetized with pentobarbital or chloralose and urediane, using the Wiederhielm servocontrolled micropipette pressure system incorporating pipette tips less than 0.5/A in diameter. During these measurements, systemic blood pressure was varied by supplemental intravenous admin...
متن کاملPressures in the Plal Arterial Microcirculation of the Cat during Changes in Systemic Arterial Blood Pressure
Dynamic arterial blood pressures were recorded by micropuncture of 99 cortical surface arteries and arterioles in cats anesthetized with pentobarbital or chloralose and urediane, using the Wiederhielm servocontrolled micropipette pressure system incorporating pipette tips less than 0.5/A in diameter. During these measurements, systemic blood pressure was varied by supplemental intravenous admin...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2019
ISSN: 0269-2813
DOI: 10.1111/apt.15439